Regulation of the cell cycle
Internal checkpoints are important.
- G1 is the restriction checkpoint (point where a cell becomes committed to the cycle), where DNA is checked to make sure there is no damage, and the cell is checked to ensure it is the correct size and has enough energy reserves (nutrients).
- G2/M is the second checkpoint, chromosomes are checked to make sure they have all been replicated, and none of it is faulty+ cell size is checked again
- M- sister chromatids are checked to confirm attachment to spindles are suitable.
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